Generation of pralatrexate resistant T‐cell lymphoma lines reveals two patterns of acquired drug resistance that is overcome with epigenetic modifiers
L Scotto, C Kinahan, B Casadei… - Genes …, 2020 - Wiley Online Library
… selectivity and acquired resistance remains elusive. In an effort to … acquired PDX resistance,
we generated resistant cells lines over a broad concentration range. PDX-resistant cell lines …
we generated resistant cells lines over a broad concentration range. PDX-resistant cell lines …
[HTML][HTML] Characterization of newly established Pralatrexate-resistant cell lines and the mechanisms of resistance
K Oiwa, N Hosono, R Nishi, L Scotto, OA O'Connor… - BMC cancer, 2021 - Springer
… exhibit intrinsic resistance or develop acquired resistance. … Gene set enrichment analysis
revealed that adipogenesis … PDX-resistant T-cell acute lymphoblastic leukemia cell lines, and …
revealed that adipogenesis … PDX-resistant T-cell acute lymphoblastic leukemia cell lines, and …
New directions in treating peripheral T-cell lymphomas (PTCL): leveraging epigenetic modifiers alone and in combination
H Ma, OA O'Connor, E Marchi - Expert Review of Hematology, 2019 - Taylor & Francis
… shows common epigenetic mutations, targets, and the drugs … a classical epigenetic modifier,
pralatrexate was the first drug … -generation epigenetic modifiers and other new drugs has the …
pralatrexate was the first drug … -generation epigenetic modifiers and other new drugs has the …
[HTML][HTML] Update on histone deacetylase inhibitors in peripheral T-cell lymphoma (PTCL)
G Lu, S Jin, S Lin, Y Gong, L Zhang, J Yang, W Mou… - … Epigenetics, 2023 - Springer
… a second-generation analog of vorinostat, belinostat (PXD101) shows … inhibitor pralatrexate
[89] have been demonstrated in T-cell … It acquired approval from the China Food and Drug …
[89] have been demonstrated in T-cell … It acquired approval from the China Food and Drug …
Precision Medicine Concepts in T-Cell Lymphoma
P Staber - Peripheral T-cell Lymphomas, 2019 - books.google.com
… The novel genetic information gained from genome-wide high-… Next-generation functional
drug screening (ngFDS) aims to … A phase 1 study of romidepsin and pralatrexate reveals …
drug screening (ngFDS) aims to … A phase 1 study of romidepsin and pralatrexate reveals …
Antifolates in cancer therapy: structure, activity and mechanisms of drug resistance
N Gonen, YG Assaraf - Drug Resistance Updates, 2012 - Elsevier
… synthase as well as pralatrexate which blocks dihydrofolate … for the development of the
next generation antifolates. Pre-… membrane topology of PCFT reveals 12 TMDs with a large …
next generation antifolates. Pre-… membrane topology of PCFT reveals 12 TMDs with a large …
[HTML][HTML] Angioimmunoblastic T-cell lymphoma and correlated neoplasms with T-cell follicular helper phenotype: from molecular mechanisms to therapeutic advances
LAPC Lage, HF Culler, CO Reichert… - Frontiers in …, 2023 - frontiersin.org
… in the 1980s by studies that revealed recurrent chromosomal … By generating an efflux pump
mechanism for … studies, the most promising appear to be romidepsin/pralatrexate (ORR 71%; …
mechanism for … studies, the most promising appear to be romidepsin/pralatrexate (ORR 71%; …
[HTML][HTML] Recent advances in T-cell lymphoid neoplasms
A Bigas, JJ Rodriguez-Sevilla, L Espinosa… - Experimental …, 2022 - Elsevier
… differentiation potential and the acquisition of functional traits. … Next-generation sequencing
has revealed recurrent genetic … and refractory PTCL-NOS: pralatrexate, the HDAC inhibitors …
has revealed recurrent genetic … and refractory PTCL-NOS: pralatrexate, the HDAC inhibitors …
[PDF][PDF] Emerging therapies in relapsed and refractory peripheral T-cell lymphoma
SH Bachow, OA O'Connor - Clin Adv Hematol Oncol, 2015 - hematologyandoncology.net
… However, recent advances in next-generation sequencing, gene expres… Indeed, in vitro
testing has established that pralatrexate … or refractory lymphoma reveals marked activity in T-cell …
testing has established that pralatrexate … or refractory lymphoma reveals marked activity in T-cell …
Inside the biochemical pathways of thymidylate synthase perturbed by anticancer drugs: Novel strategies to overcome cancer chemoresistance
… (Tomudex) and pralatrexate are structural folate antagonists of … pralatrexate are known to
inhibit TS as their primary drug … related to drug toxicity and the development of drug resistance, …
inhibit TS as their primary drug … related to drug toxicity and the development of drug resistance, …